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2021

Efficacy and safety of nitazoxanide plus atazanavir/ritonavir for the treatment of moderate to severe COVID-19 (NACOVID): A structured summary of a study protocol for a randomised controlled trial

A Olagunju, A Fowotade, A Olagunoye, TO Ojo, BO Adefuye, AF Fagbamigbe, AO Adebiyi, OI Olagunju, OT Ladipo, A Akinloye, BA Adeagbo, A Onayade, OO Bolaji, C Happi, 

S Rannard & A Owen

Trials 2021, 22, 3 

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Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

JJ Hobson, AC Savage, AB Dwyer, C Unsworth, J Massam, U Arshad, H Pertinez, H Box,

L Tatham, RKR Rajoli, M Neary, J Sharp,

A Valentijn, C David, P Curley, NJ Liptrott,

TO McDonald, A Owen, SP Rannard

Nanoscale, 2021, 13, 6410 - 6416 

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Development of a highly sensitive bioanalytical assay for the quantification of favipiravir

P Curley, M Neary,U Arshad, L Tatham, H Pertinez, H Box, RKR Rajoli, A Valentijn, J Sharp, 

SP Rannard, A Owen

BioRxiv 2021; DOI: https://doi.org/10.1101/2021.02.03.429628

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Redispersible Nanosuspensions as a Plausible Oral Delivery System for Curcumin  

NM Elbaz, LM Tatham, A Owen, S Rannard, TO McDonald

Food Hydrocolloids., 2021, 121, 107005

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Optimisation and validation of a sensitive bioanalytical method for niclosamide

U Arshad, H Pertinez, H Box, L Tatham, R Rajoli, M Neary, J Sharp, A Valentijn, J Hobson, C Unsworth, A Dwyer, A Savage, TO McDonald, S Rannard, P Curley, A Owen,

BioRxiv 2021; DOI: https://doi.org/10.1101/2021.01.13.426426

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Dose prediction for repurposing nitazoxanide in

SARS-CoV-2 treatment or chemoprophylaxis

RKR RajoliH PertinezU ArshadH BoxL TathamP CurleyM NearyJ SharpNJ Liptrott

A ValentijnC DavidSP RannardG Aljayyoussi

SH PenningtonA HillM BoffitoSA WardSH KhooPG BrayPM O'NeillWD Hong

G Biagini, A Owen

Br. J. Clin. Pharmacol., 2021, 87, 2078–2088

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Quantification of branching within high molecular weight polymers with polyester backbones formed by transfer-dominated branching radical telomerisation (TBRT)

S Cassin, S Flynn, P Chambon & SP Rannard

RSC Advances, 2021, 11, 24374 - 24380

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Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research

M Neary, U Arshad, L Tatham, H Pertinez, H Box, RK Rajoli, A Valentijn, J Sharp, SP Rannard, GA Biagini, P Curley, A Owen

BioRxiv 2021; DOI:10.1101/2021.05.27.445500 

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Evaluation of intranasal nafamostat or camostat for SARS-CoV-2 chemoprophylaxis in Syrian golden hamsters

M Neary, H Box, J Sharp, L Tatham, P Curley, J Herriott, E Kijak, U Arshad, JJ Hobson, RKR Rajoli, H Pertinez, A Valentijn, K Dhaliwal, F McCaughan, SP Rannard, A Kipar, JP Stewart,  A Owen

BioRxiv 2021; DOI:10.1101/2021.07.08.451654

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Impact of Long-Acting Therapies on the Global HIV Epidemic

N C. Chandiwana, C. M. Serenata, A. Owen, S. Rannard; C. Perez Casas, C. Scott, A. HILL, P. Clayden, C Flexner

AIDS, 2021, 35 (Supplement 2), S137-S143

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Impact of multi-vinyl taxogen dimensions on high molecular weight soluble polymer synthesis using Transfer-dominated Branching Radical Telomerisation

O.B. Penrhyn-Lowe, S Flynn, S. R. Cassin, S Mckeating, S Lomas, S Wright, P Chambon and

S. P. Rannard

Polymer Chem., 2021, 12, 6472 - 6483

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Evaluating the impact of systematic hydrophobic modification of model drugs on the control, stability and loading of lipid-based nanoparticles

C Hogarth, K Arnold, A McLauchlin, S Rannard,

M Siccardi, TO McDonald

J. Mater. Chem. B, 2021, 9, 9874-9884

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Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: phase 1b/2a experimental study to investigate safety, pharmacokinetics and pharmacodynamics

T. M. Quinn, E. E. Gaughan, A. Bruce, J. Antonelli, R. O'Connor, F. Li, S. McNamara, O. Koch, C. MacIntosh, D. Dockrell, T. Walsh, K. G. Blyth, C. Church, J. Schwarze, C. Boz, A. Valanciute, M. Burgess, P. Emanuel, B. Mills, G. Rinaldi, G. Hardisty, R. Mills, E. Findlay, S.  Jabbal, A. Duncan, S. Plant, A. D. L. Marshall, I. Young, K. Russell, E. Scholefield, A. F. Nimmo, I. B. Nazarov, G. C. Churchill, J. S. O. McCullagh, K. H. Ebrahimi, C. Ferrett, K. Templeton, S. Rannard, A. Owen, A. Moore, K. Finlayson, M. Shankar-Hari, J. Norrie, R. A.  Parker, A. R. Akram, D. C. Anthony, J. W. Dear, N. Hirani, K. Dhaliwal

medRxiv 2021 DOI: 10.1101/2021.10.06.21264648

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2020

Controlled Synthesis of Calcium Carbonate Nanoparticles and Stimuli-Responsive Multi-Layered Nanocapsules for Oral Drug Delivery
N Elbaz, A Owen, S Rannard, T McDonald

Int. J. Pharmaceutics. 2020,  574,  118866 

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Architectural control of polystyrene physical properties using branched anionic polymerisation initiated at ambient temperature

T Alhilfi, P Chambon, S. P. Rannard

J. Polym. Sci., Part A: Poly. Chem., 2020, 58, 1426-1438

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Safety assessment of a new nanoemulsion-based drug delivery system reveals unexpected, drug-free, anticoagulant activity

JJ Hobson, SP Rannard, A Owen, NJ Liptrott

Nanomedicine 2020, 15, 1361-1373

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Chasing COVID-19 chemotherapeutics without putting the cart before the horse

S Rannard, T McDonald, A Owen

British Journal of Clinical Pharmacology 2020, accepted DOI: 10.22541/au.159413561.14757083

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Optimization of the Synthetic Parameters of Lipid Polymer Hybrid Nanoparticles Dual Loaded with Darunavir and Ritonavir for the Treatment of HIV

H Elkateb,LM Tatham, H Cauldbeck,

E Niezabitowska, A Owen, S Rannard T McDonald

Int. J. Pharmaceutics, 2020,588, 119794

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Designing single trigger/dual-response release and degradation into amine-functional hyperbranched-polydendron nanoprecipitates

HE Rogers, P Chambon, S Flynn, FY Hern, A Owen, SP Rannard

Nanoscale Adv, 2020, 2, 5468 - 5477

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Critical considerations for targeting metastatic colorectal cancer with nanotechnology

U Arshad, C Goldring, P Sutton, M Ashford, K Treacher, S Rannard, A Owen

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2020, 12(2), e1588

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Prioritisation of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics

U Arshad, H Pertinez, H Box, L Tatham, RKR  Rajoli, P Curley, M Neary, J Sharp, NJ Liptrott, A Valentijn,

C David, SP Rannard, P O'Neill, G Aljayyoussi, 

S Pennington, SA Ward, DJ Back, SH Khoo, PG Bray, G Biagini, A Owen

Clin. Pharmacol. Ther., 2020, 108, 775-790

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Mucus-responsive functionalized emulsions: Design, synthesis and study of novel branched polymers as functional emulsifiers

SE. Edwards, S Flynn, JJ. Hobson, P Chambon, H Cauldbeck S P Rannard

RSC Adv., 2020, 10, 30463-30475

Insights into the Internal Structures of Nanogels Using a Versatile Asymmetric-Flow Field-Flow Fractionation Method

E Niezabitowska, AR Town, B Sabagh, MD 

Morales Moctezuma, VR Kearns, SG. Spain, SP Rannard TO McDonald

Nanoscale Adv., 2020, doi.org/10.1039/D0NA00314J

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Using pyrene to probe the effects of poloxamer stabilisers on internal lipid microenvironments in solid lipid nanoparticles.

JM Taylor,  K Scale, S Arrowsmith, A Sharp,

S Flynn, S Rannard, TO McDonald  

Nanoscale Adv., 2020,2, 5572-5577

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Hyperbranched polymers with step-growth chemistries from transfer-dominated branching radical telomerisation (TBRT) of divinyl monomers.

SR Cassin, P Chambon, SP Rannard

Polymer Chem., 2020, 11, 7637 - 7649

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2020

2019

Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies
J J Hobson, A Al-khouja,  P Curley,  D Meyers,  C Flexner, M Siccardi, A Owen, C Freel Meyers,  S P Rannard
Nature Communications 2019, 10, 1​413

On the issue of transparency and reproducibility in nanomedicine

H. S. Leong et al
Nature Nanotechnology 2019, 14, 629

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Long-Acting Injectable Statins—Is It Time for a Paradigm Shift?

L M TathamN J Liptrott, S P Rannard, A Owen 
Molecules 2019, 24(15), 2685

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Expanding the monomer scope of linear and branched vinyl polymerisations via copper-catalysed reversible-deactivation radical polymerisation of hydrophobic methacrylates using anhydrous alcohol solvents.

S Flynn, A B Dwyer, P Chambon, S Rannard
Polymer Chem. 2019, 10, 5103 - 5115

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Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

J J Hobson, P Curley, A C Savage, A Al-khouja,  M Siccardi, C Flexner, C Freel Meyers, A Owen, S P Rannard

Nanoscale Advances, 2019, 1(11), 4301-4307

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Extending Dendrimer Chemistry to Unique Macromolecular Architectures

A B Dwyer and S P Rannard

RSC Monographs in Supramolecular Chemistry, Dendrimer Chemistry, 2019, accepted

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2019
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