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2015

The application of nanotechnology to drug delivery in Medicine.

T. O. McDonald, M. Siccardi, D. Moss, N. Liptrott,

M. Giardiello, S. Rannard & A. Owen

Nanoengineering: Global Approaches to Health and Safety Issues. P. Dolez (Ed), Elsevier Health Sciences, Toronto, 2015, Chapter 2.2, 173-223

ISBN: 978-0-444-62747-6

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Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents

A. W. Jackson , P. Chandrasekharan, J. Shi,

S. P. Rannard, Q. Liu, C. T. Yang & T. He

Int J Nanomedicine, 2015, 10, 5895—5907

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Considerations for clinically-relevant nanomedicine therapies for chronic diseases

A. Owen & S. P. Rannard

Nanomedicine (Lond.), 2015 10, 3103–3107

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Augmented inhibition of CYP3A4 in human primary hepatocytes by ritonavir solid drug nanoparticles

P, Martin, M. Giardiello, T. McDonald, D. Smith,

M. Siccardi, S. Rannard & A Owen,

Mol. Pharmaceutics 2015,12, 3556–3568

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Synthesis, nanoprecipitation and pH sensitivity of amphiphilic linear-dendritic hybrid polymers and hyperbranched-polydendrons containing tertiary amine functional dendrons

H. E. Rogers, P. Chambon, S. E. R. Auty, F. Y. Hern, A. Owen & S. P. Rannard

Soft Matter, 2015, 11, 7005-7015

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Exploring the homogeneous controlled radical polymerisation of hydrophobic monomers in anti-solvents for their polymers: RAFT and ATRP of various alkyl methacrylates in anhydrous methanol to high conversion and low dispersity.

A. B. Dwyer, P. Chambon, A. Town, F. L. Hatton,

J. Ford & S. P. Rannard.

Polym.Chem. Sci., 2015, 6, 7286 - 7296

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Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions

N. J. Liptrott , M. Giardiello , J. W Hunter , L. Tatham , L. R Tidbury , M. Siccardi, S. Rannard & A. Owen

Nanomedicine (London) 2015, 10, 1407-1421

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Nanoformulation strategies for the enhanced oral bioavailability of antiretroviral therapeutics.

L. Tatham, S. P. Rannard & A. Owen

Ther. Deliv., 2015, 6, 469-490

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Multiple and Co-Nanoprecipitation Studies of Branched Hydrophobic Copolymers and A–B Amphiphilic Block Copolymers, Allowing Rapid Formation of Sterically Stabilized Nanoparticles in Aqueous Media.

J. Ford, P. Chambon, J. North, F. L. Hatton,

M. Giardiello, A. Owen & S P. Rannard

Macromolecules, 2015, 48, 1883-1899

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Physiologically Based Pharmacokinetic Modelling to Inform Development of Intra-muscular Long-Acting Nanoformulations for HIV

R. K. R. Rajoli, D. J. Back, S. Rannard,

C. L. Freel Meyers, C. Flexner, A. Owen & M. Siccardi

Clin. Pharmacokinet., 2015, 54, 639-650.

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One-pot’ sequential deprotection/functionalisation of linear-dendritic hybrid polymers using a xanthate mediated thiol/Michael addition.

S. E. R. Auty, O. C. J. Andrén, F.Y. Hern, M. Malkoch & S. P. Rannard

Polym. Chem., 2015, 6, 573 - 582

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Hyperbranched Polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium.

F. L. Hatton, L. M. Tatham, L. R. Tidbury, P. Chambon, T. He, A. Owen & S. Rannard

Chem. Sci., 2015, 6(1), 326 - 334

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2014

2014

Partial mitigation of gold nanoparticle-interactions with human lymphocytes by surface functionalization with a ‘mixed-matrix’

N. J. Liptrott, E. Kendall, D. J. Nieves, J. Farrell, S. Rannard, D. G Fernig & A. Owen

Nanomedicine (London) 2014, 9, 2467-2479

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The application of nanotechnology in

medicine: treatment and diagnostics

A. Owen, C. Dufès, D. Moscatelli, E. Mayes, J. F. Lovell, K. V. Katti, K. Sokolov, M. Mazza, O. Fontaine, S. Rannard & V. Stone

Nanomedicine, 2014, 9(9), 1291–1294

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The First Peripherally Masked Thiol Dendrimers: A Facile and Highly Efficient Functionalization Strategy of Polyester Dendrimers via One-Pot Xanthate Deprotection/Thiol-Acrylate Michael Addition Reactions.

S. E. R. Auty, O. Andrén, M. Malkoch & S. P. Rannard

Chem. Commun. 2014, 50, 6574 - 6577

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Is methanol really a bad solvent for poly(n-butyl methacrylate)? Low dispersity and high molecular weight polymers of n-butyl methacrylate synthesised via ATRP in anhydrous methanol.

A. B. Dwyer, P. Chambon, A. Town, T. He, A. Owen & S. P. Rannard

Polym.Chem. 2014, 5 (11), 3608 - 3616

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Hyperbranched Polydendrons: a new controlled macromolecular architecture with self-assembly in water and organic solvents.

F. L. Hatton, P. Chambon, T. O. McDonald,

A. Owen & S. P. Rannard

Chem. Sci., 2014, 5(5), 1844 - 1853

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Antiretroviral Solid Drug Nanoparticles with Enhanced Oral Bioavailability: Production, Characterisation and In Vitro-In Vivo Correlation.

T. O. McDonald, M. Giardiello, P. Martin, M. Siccardi, N. J. Liptrott, D. Smith, P. Roberts, P. Curley, A. Schipani, S. H. Khoo, J. Long, A. J. Foster, S. P. Rannard & A. Owen

Adv. Healthcare Mater., 2014, 3, 400–411

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2013

2013

High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli

T. O. McDonald, L. M. Tatham, F. Y. Southworth, M. Giardiello, P. Martin, N. J. Liptrott, A. Owen

& S. P. Rannard

J. Mater. Chem. B, 2013, 1, 4455-4465

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Reactions of hydrophobic organic nanoparticle mixtures in water: Nanoparticle-on-nanoparticle oxidative dye bleaching

M. Giardiello,T. O. McDonald, J-S. Lee,

A. D. Roberts, A. Owen & S. P. Rannard

Green Chem., 2013, 15(6), 1590-1599

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Mediation of in vitro cytochrome P450 activity by common pharmaceutical excipients

P. Martin, M. Giardiello, T. O. McDonald,

S. P. Rannard & A. Owen

Mol. Pharmaceutics 2013, 107, 2739–2748

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Research Spotlight: Nanomedicines for HIV therapy

M. Siccardi, P. Martin, T. O. McDonald, N. J. Liptrott, M. Giardiello, S. Rannard & A. Owen

Therapeutic Delivery 2013, 4(2), 153-156

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Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz

M.Siccardi, A. Olagunju, K. Seden, F. Ebrahimjee,

S. Rannard, D. Back & A. Owen

In Silico Pharmacology 2013, 1, 4

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