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2022

Dual-responsive degradable core–shell nanogels with tuneable aggregation behaviour

D M GrayA R Town, E Niezabitowska

S P Rannard and  T . McDonald    

RSC Adv., 2022,12, 2196-2206

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Lack of Ronapreve (REGN-CoV; casirivimab and imdevimab) virological efficacy against the SARS-CoV 2 Omicron variant (B.1.1.529) in K18-hACE2 mice

LTatham, J Sharp, E Kijak, J Herriott, M Neary, H Box, A Valentijn, H Cox, H Pertinez, P Curley, U Arshad, RKR Rajoli, S Rannard, JStewart, A Owen

BioRxiv, 2022,10.1101/2022.01.23.477397v1

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Randomised Controlled Trial of Intravenous Nafamostat Mesylate in COVID pneumonitis: Phase 1b/2a Experimental Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics

TM Quinn, EE Gaughan, A Bruce, J Antonelli, R O’Connor, F Li, S McNamara, O Koch, C MacIntosh, D Dockrell, T Walsh,  KG Blyth, C Church, J Schwarze, C Boz, A Valanciute, M Burgess, P Emanuel, B Mills, G Rinaldi, G Hardisty, R Mills, E Findlay, S Jabbal, A Duncan, S Plant, ADL Marshall, I Young, K Russell, E Scholefield, AF Nimmo, IB Nazarov, GC Churchill, JSO McCullagh, KH Ebrahimi, C Ferrett, K Templeton, S Rannard, A Owen, A Moore, K Finlayson, M Shankar-Hari, J Norrie, RA. Parker,  AR Akram, DC Anthony, JW Dear, N Hirani, K Dhaliwal 

EBioMedicine, 2022, 76, 103856

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Accessing New and Scalable High Molecular Weight Branched Copolymer Structures using Transfer-dominated Branching Radical Telomerisation (TBRT)

S R Cassin, S Flynn. P Chambon & S P Rannard

Polym. Chem., 2022, 13, 2295 - 2306

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Linear and branched polymer prodrugs of the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine as structural materials for long-acting implants​
A Shakil, F Y Hern, C Liu, K Temburnikar, P Chambon, N Liptrott, T O McDonald, M. Neary, A. Owen, C Freel Meyers, S P Rannard
 J. Mater. Chem. B, 2022,10, 4395 - 4404

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Controlling the pH-response of branched copolymer nanoprecipitates synthesised by Transfer-dominated Branching Radical Telomerisation (TBRT) through telogen chemistry and spatial distribution of tertiary amine functionality.

O B. Penrhyn-LoweS R CassinP Chambon & 

S Rannard  

Nanoscale Adv., 2022, 4, 4051-4058

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A randomised, open-label trial of combined nitazoxanide and atazanavir/ritonavir for mild to moderate COVID-19

A Fowotade, F Bamidele, B Egbetola, A F Fagbamigbe, B A Adeagbo, B O Adefuye, A Olagunoye, T O Ojo, A O Adebiyi, O I Olagunju, O T Ladipo, A Akinloye, A Onayade,  O Bolaji, S Rannard, C Happi, A Owen & A Olagunju

Frontiers in Medicine, 2022, 2022, 9, 956123 

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Using temperature to modify the reaction conditions and outcomes of polymers formed using Transfer-dominated Branching Radical Telomerisation (TBRT)

S Flynn, O B. Penrhyn-Lowe, S Mckeating, 

S Wright, S Lomas, S R Cassin, P Chambon & S P Rannard

RSC Adv. 2022, 2022,12, 31424-31431

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2023

2023

Nanomedicine strategies to improve therapeutic agents for the prevention and treatment of preterm birth and future directions

J Taylor,  A Sharp, S Rannard, S Arrowsmith,  

T O McDonald.

Nanoscale Adv. 2023, 5, 1870-1889

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Utilising the effect of reaction concentration to tune the physical properties of hyperbranched polymers synthesised using Transfer-dominated Branching Radical Telomerisation (TBRT)

SR Cassin, S Wright, S Mckeating, OB Penrhyn-Lowe, S Flynn, S Lomas, P Chambon, SP Rannard

Polym. Chem. 2023, 14,1905-1914

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High drug loading solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsions for the dual drug delivery of the HIV drugs darunavir and ritonavir

H Elkateb, H Cauldbeck, E Niezabitowska, C Hogarth, K Arnold, S Rannard, T O McDonald

JCIS Open 2023, DOI: 10.1016/j.jciso.2023.100087

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Layer by layer self-assembly for coating a nanosuspension to modify drug release and stability for oral delivery

N M Elbaz, L M Tatham, A Owen, 

S Rannard, T O McDonald

Food Hydrocolloids 2023, DOI: 10.1016/j.foodhyd.2023.108908

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Understanding the Degradation of Core-Shell Nanogels Using Asymmetrical Flow Field Flow Fractionation

E Niezabitowska, D M Gray, E Gallardo-Toledo, A Owen, S P Rannard and 

T O McDonald

J. Funct. Biomater. 2023, 14(7), 346

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Preferences of patients and providers in high-burden malaria settings for long-acting malaria chemoprevention

K Scarsi, H Sayles, K Kapungu, P Sifuna, M Ippolito, R Furl, M Anderson, J Dountio, Ofimboudem, G Chongwe, J Hutter, S Rannard, A Owen, S Swindells,  Am. J. Trop. Med. Hyg.2023 (accepted) 

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Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations

P Curley, J J Hobson, N J Liptrott, E Makarov, A Al-khouja, L Tatham, C A W David, H Box, M Neary, J Sharp, H Pertinez, D Meyers, C Flexner, C L Freel Meyers, L Poluektova, S Rannard, A Owen

Pharmaceutics 2023, 15, 1835

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Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy

Y S Chang, S-Y Li, H Pertinez, F Betoudji, J Lee, 

S P Rannard,  A Owen, E L Nuermberger,

N C Ammerman,   

Antimicrob. Agents and Chemother. 2023, 67, e0048123

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Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research

M Neary, U Arshad, L Tatham, H Pertinez, H Box, R K R Rajoli, A Valentijn, J Sharp, S P Rannard, G A Biagini, P Curley, A Owen 

J Chromatography B, 2023, 1228, 123823

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Evaluation of nafamostat as chemoprophylaxis for SARS-CoV-2 in hamsters
M Neary, J Sharp, E Gallardo-Toledo, J Herriott,
E Kijak, C Bramwell, H Cox, L Tatham, H Box, P Curley,
U Arshad, R K R Rajoli, H Pertinez, A Valentijn, K
Dhaliwal, F Mccaughan, J J Hobson, S Rannard, A Kipar, J Stewart, A Owen

Viruses, 2023, manuscript accepted

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Polymer-prodrug conjugates as candidates for degradable, long-acting implants, releasing the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine

C Liu, F Y Hern, A Shakil, K Temburnikar, P Chambon, N Liptrott, T O McDonald, M Neary, C Flexner, A Owen, C Freel Meyers, S P Rannard 

J. Mater. Chem. B, 2023, DOI 10.1039/D3TB02268D

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Exploring telogen chemical structure and reactivity when forming highly branched polyesters derived from ethylene glycol dimethacrylate homopolymerisation under Transfer-dominated Branching Radical Telomerisation (TBRT) conditions
S Flynn, B Linthwaite, OB Penrhyn-Lowe,

S Mckeating, S Wright, SR Cassin, P Chambon, SP Rannard,

Polym. Chem., 2023,14, 5102-5114

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Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters  

H Box, J Sharp, S Pennington, E Kijak, L Tatham,

CH Caygill, RC Lopeman, L Jeffreys, J Herriott,

M Neary, A Valentijn, H Pertinez, P Curley, U Arshad, RK Rajoli, J Reddy; D Jochmans, L Vangeel, J Neyts,

E Chatelain, F Escudié, I Scandale, S Rannard,

J Stewart, G Biagini, A Owen

Antimicrob. Agents and Chemother. 2023, accepted

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Ex vivo transdermal delivery of 3H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

S Morris, M Long, A Savage, A Owen,

S Rannard, H Cauldbeck

Nanoscale Adv., 2023

DOI: 10.1039/d3na00454f

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Physiologically Based Pharmacokinetic Modelling of Cabotegravir MicroArray Patches in Rats and Humans

H Kinvig, RKR Rajoli, H Pertinez, LK Vora, F Volpe-Zanutto, RF Donnelly, S Rannard, C Flexner, M Siccardi, A Owen

Pharmaceutics, 2023, accepted 

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2024

2024

Navigating the Challenges of Lipid Nanoparticle Formulation: The Role of Unpegylated Lipid Surfactants in Enhancing Drug Loading and Stability

C Hogarth, K Arnold, S Wright, H Elkateb, S Rannard, T O McDonald

Nanoscale Adv. 2024, 6, 669-679

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Preferences and Feasibility of Long-Acting Technologies for Treatment of Hepatitis C Virus in Low- and Middle-Income Countries: A Survey of Providers and Policymakers

N Gupta, S Swindells, KK Scarsi, R Furl, D Thomas, ED Weld, JD Ofimboudem, H Desalegn, S Hamid, A Rosas, A Owen, S Rannard, L Hiebert, K Sun, J Ward

J Viral Hepatitis  2024, 31, 221-232

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Atazanavir/ritonavir increased tizoxanide exposure from oral nitazoxanide through pharmacokinetic interaction in healthy volunteers

A Akinloye, T Oyedeji, O Eniayewu, B A Adeagbo,

O Bolaji, S Rannard, A Owen, A Olagunju

Future Pharmacol. 2024, 4, 163-172

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Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV‑2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case

LTatham, A Kipar, J Sharp, E Kijak, J Herriott, M Neary, H Box, E Gallardo Toledo, A Valentijn, H Cox, H Pertinez, P Curley, U Arshad, R K R Rajoli, S Rannard, J Stewart, A Owen

Microbiol Spectr 2024, 12, e03916-23

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Clinical, Pharmacological, and Qualitative Characterization of Drug-Drug Interactions in Pregnant Women Initiating HIV Therapy in Sub-Saharan Africa  

D Kiiza, D Rostami-Hochaghan, Y Alhassan, K Seden, H Reynolds, JP Kaboggoza, M Taegtmeyer, T Chen, E Challenger, T Malaba, D Wang, L Else, F Hern, J Sharp, M Neary, S Penchala, C Waitt, C Orrell, A Colbers, L Myer, A Owen, S Rannard, S Khoo, M Lamorde

J. Antimicrob. Chemother. 2024, accepted

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Systemic delivery of bictegravir and tenofovir alafenamide using dissolving microneedles for HIV preexposure prophylaxis

C Zhang,Y Wu, ARJ Hutton, AH Bin Sabr, JJ Hobson, AC Savage, HO McCarthy, AJ Paredes, A Owen, SP Rannard, RF Donnelly

Int J Pharma 2024, 660, 124317

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Employing Transfer-dominated Branching Radical Telomerisation (TBRT) and Atom Transfer Radical Polymerisation (ATRP) to form complex polyester-polymethacrylate branched-linear star copolymer hybrids via orthogonal initiation

AB Dwyer, WM Sandy, FY Hern, OB. Penrhyn-Lowe, S McKeating, S Flynn, S Wright, S Pate, P Chambon,

SP Rannard

Chem Comm. 2024, 60, 10116-10119

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Controlling enzyme hydrolysis of branched polymers synthesised using TBRT via telogen and taxogen selection

S Mckeating, OB. Penrhyn-Lowe, S Flynn, SR. Cassin, S Lomas, C Fidge, P Price, S Wright, P Chambon, SP Rannard

Comm. Chem (Nature) 2024, 7, 197

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Preferences and Feasibility of Long-Acting Technologies for the Treatment of Hepatitis C Virus: A Survey of Patients in Diverse Low- and Middle-Income Countries

R Furl, K K Scarsi, H Sayles, M Anderson, J Dountio Ofimboudem, E D Weld, I Waked, A Gomaa, A Al-Khatib, F M Elshobary, H Desalegn, H Fisseha, S Solomon, S Mehta, A Owen, S Rannard, D L Thomas, S Swindells

J Viral Hepatitis  2024, doi.org/10.1111/jvh.14031

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© 2018 

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