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2018

Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems
J. J. Hobson, S. Edwards, R. A. Slater, P. Martin, A. Owen & S P. Rannard
RSC Advances,  2018, 8, 12984 - 12991​

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Towards a Maraviroc Long-Acting Injectable Nanoformulation
L.M. Tatham, A. C. Savage, A. Dwyer, M. Siccardi, T. Scott, M. Vourvahis, A. Clarke, S. P. Rannard & A. Owen.
European Journal of Pharmaceutics and Biopharmaceutics, 2018,  S0939-6411(18)30200-5

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Co-initiated hyperbranched-polydendron building blocks for the direct nanoprecipitation of dendron-directed patchy particles with heterogeneous surface functionality.
F. Y. Hern,  A. Hill,  A. Owen  and  S. Rannard 
Polym. Chem., 2018, 9, 1767 - 1771

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Improving maraviroc oral bioavailability by formation of solid drug nanoparticles

A.C. Savage, L.M. Tatham, M. Siccardi, A. Owen, T. Scott, M. Vourvahis, A. Clark & S.P. Rannard

European Journal of Pharmaceutics and Biopharmaceutics, 2018, S0939-6411(18)30165-6

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Inhibitory Effects of Commonly Used Excipients on P-Glycoprotein in Vitro

R. Gurjar , C. Y. S. Chan, P. Curley, J. Sharp, J. Chiong, 

S. Rannard, M. Siccardi & A. Owen

Mol. Pharmaceutics, 2018, 15, 4835–4842

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Assessment of interactions of efavirenz solid drug nanoparticles with human immunological and haematological systems
N. J. Liptrott, M. Giardiello, T. O. McDonald, S. P. Rannard & A. Owen
Journal of Nanobiotechnology, 2018, 16, 22

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Modulated release from implantable ocular silicone oil tamponade drug reservoirs.
H. Cauldbeck, M. Le Hellaye, T. O. McDonald, M. Long, R. L. Williams, S. P. Rannard and V. R. Kearns
J. Polym. Sci., Part A: Poly. Chem., 2018, 56, 938–946

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Long-acting injectable atovaquone nanomedicines for malaria prophylaxis. 
R. P. Bakshi, L. Tatham, A. C. Savage, A. K. Tripathi, G. Mlambo, M. M. Ippolito, E. Nenortas, S. P. Rannard, A. Owen, T. A. Shapiro
Nature Communications, 2018, 9, 315

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In Silico Dose Prediction for Long-​Acting Rilpivirine and Cabotegravir Administration to Children and Adolescents

R.K.R. Rajoli, D.J. Back, A. Owen, M. Siccardi,

S.P. Rannard, C. F. Meyers & C. Flexner 

Clinical Pharmacokinetics 2018, 57, 255-266

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The emerging role of physiologically based pharmacokinetic modelling in solid drug nanoparticle translation

M. Siccardi, S. Rannard & A. Owen 

Advanced Drug Delivery Reviews 2018, 131, 116-121. 

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The potential value of nanomedicine and novel oral dosage forms in the treatment of HIV

J. J Hobson, A. Owen & S. P Rannard

Nanomedicine (London), 2018, 13, 1963-1965

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2017

2017

In Situ Xanthate Deprotection to Generate Thiol Chain Transfer Agents for Conventional Free Radical Linear and Branched Vinyl Polymerisation

S. Flynn, S. D. Dale, A. B. Dwyer, P. Chambon & S. P. Rannard

J. Polym. Sci., Part A: Poly. Chem., 2017, 55, 3963-3967

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In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line

P. Curley, M. Giardiello, N. J. Liptrott, D. Dickens, D. M. Moss, J. Hobson, A. C. Savage, T. O. Mcdonald, M. Siccardi, S. Rannard & A. Owen

JOIN, 2017, 2, 157-169

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Intracellular delivery of nano-formulated anti-tuberculosis drugs enhances bactericidal activity

S. Donnellan, V. Stone, C. Watkins, M. Gardiello, S. Rannard, A. Owen, H. Johnston, B. Swift, G. Aljayyoussi, J. McLuckie & K. Stevenson

JOIN, 2017, 2, 146-156

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Lack of interaction of lopinavir solid drug nanoparticles with cells of the immune system

N. J. Liptrott, M. Giardiello, T. O. McDonald, S. P. Rannard & A. Owen

Nanomedicine, 2017,12, 2043-2054

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MADIX polymerization of vinyl acetate using ethyl acetate as a green solvent; near-complete monomer conversion with molecular weight control

M. E. Levere,  P. Chambon,  S. P. Rannard &

T. O. McDonald

J. Polym. Sci., Part A: Poly. Chem., 2017, 55, 2427–2431

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Model studies of the sequential and simultaneous statistical modification of dendritic functional groups and their implications within complex polymer architecture synthesis

F. Y. Hern, S. E. R. Auty, O. C. J. Andrén, M. Malkoch & S. P. Rannard

Polym. Chem., 2017, 8, 1644-1653 

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Simulating intestinal transporter and enzyme activity in a physiologically based pharmacokinetic model for tenofovir disoproxil fumarate

D. M.  Moss, P. Domanico, M. Watkins, S. Park, R.  Randolph, S. Wring, R. K. R. Rajoli, J. Hobson, S. Rannard, M. Siccardi & A. Owen

Antimicrob. Agents and Chemother., 2017, 61, e00105-17/1-e00105-17/9

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2016

2016

Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies

M. Giardiello, N. J. Liptrott, T. O. McDonald, D. Moss, M. Siccardi, P. Martin, D. Smith, R. Gurjar, S. P. Rannard & A. Owen

Nature communications 2016, 7, 13184.

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Controlling drug release from non-aqueous environments: Moderating delivery from ocular silicone oil drug reservoirs to combat proliferative vitreoretinopathy

H. Cauldbeck, M. Le Hellaye, M. Long, S. M. Kennedy, R. L. Williams, V. R, Kearns & S. P. Rannard

Journal of Controlled Release, 2016, 244, 41-51

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Towards a rational design of solid drug nanoparticles with optimised pharmacological properties

M. Siccardi, P. Martin, D. Smith, P. Curley, T. McDonald, M. Giardiello, N. Liptrott,

S. Rannard & A. Owen

JOIN, 2016, 1, 110-123

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Solid drug nanoparticles: methods for production and pharmacokinetic benefits

A. Owen & S. Rannard

Handbook of Clinical Nanomedicine: From Bench to Bedside, Eds R. Bawa, G. F. Audette, I. Rubinstein, Pan Stanford Publishing, Singapore

2016, Volume 1, Section2  211-232

ISBN 9789814316170

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APS 6th International PharmSci Conference 2015 Report

Emerging nanomedicine applications and

manufacturing: progress and challenges

F. Sartain, F. Greco, K. Hill, S. Rannard & A. Owen

Nanomedicine (Lond.), 2016, 11, 577-580

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Stable, polymer-directed and SPION-nucleated magnetic amphiphilic block copolymer nanoprecipitates with readily reversible assembly in magnetic fields.

M. Giardiello, F. L. Hatton, R. A. Slater, P. Chambon, J. North, A. K. Peacock, T. He,

T. O. McDonald, A. Owen & S P. Rannard

Nanoscale, 2016, 8, 7224 - 7231

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Strengths, weaknesses, opportunities and challenges for long acting injectable therapies: insights for applications in HIV therapy

A. Owen & S. P. Rannard

Adv. Drug Del. Rev., 2016, 103, 144–156

Role of highly branched, high molecular weight polymer structures in directing uniform polymer particle formation during nanoprecipitation

F. L. Hatton, P. Chambon, A. C. Savage & S. P. Rannard.

Chem. Commun., 2016, 52, 3915 - 3918

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